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Michel Lebel Selected Research

Werner Syndrome (Werner's Syndrome)

10/2021The Impact of Vitamin C on Different System Models of Werner Syndrome.
10/2018Nonfunctional mutant Wrn protein leads to neurological deficits, neuronal stress, microglial alteration, and immune imbalance in a mouse model of Werner syndrome.
1/2018Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein.
1/2018Serum vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein.
12/2015Impact of vitamin C on the cardiometabolic and inflammatory profiles of mice lacking a functional Werner syndrome protein helicase.
1/2015Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice.
10/2014Expression profile of Caenorhabditis elegans mutant for the Werner syndrome gene ortholog reveals the impact of vitamin C on development to increase life span.
9/2012Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging.
3/2011Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome.
6/2010Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin.
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Michel Lebel Research Topics

Disease

21Werner Syndrome (Werner's Syndrome)
10/2021 - 01/2002
11Neoplasms (Cancer)
07/2015 - 09/2002
10Premature Aging
10/2018 - 01/2010
4Inflammation (Inflammations)
12/2015 - 07/2009
4Breast Neoplasms (Breast Cancer)
06/2013 - 01/2008
3Hypertriglyceridemia
09/2014 - 06/2010
3Insulin Resistance
03/2011 - 02/2006
2Chronic Disease (Chronic Diseases)
11/2021 - 03/2016
2Cardiovascular Diseases (Cardiovascular Disease)
12/2015 - 01/2015
2Colonic Neoplasms (Colon Cancer)
07/2015 - 11/2011
2Ovarian Neoplasms (Ovarian Cancer)
06/2013 - 04/2008
2Adenocarcinoma
11/2011 - 04/2008
2Hyperglycemia
03/2011 - 06/2010
1Acute-Phase Reaction
11/2021
1Fanconi Anemia (Fanconi's Anemia)
01/2019
1Metabolic Bone Diseases (Osteopenia)
01/2018
1Infertility (Sterility)
01/2018
1Carcinoma (Carcinomatosis)
01/2015
1Neoplasm Metastasis (Metastasis)
01/2015
1Urinary Bladder Neoplasms (Bladder Cancer)
01/2015
1Atherosclerosis
09/2014
1Ovarian Epithelial Carcinoma
06/2013
1Hypoxia (Hypoxemia)
08/2012
1Colorectal Neoplasms (Colorectal Cancer)
11/2011
1Fatty Liver
03/2011
1Lymphoma (Lymphomas)
03/2011
1Carcinogenesis
03/2011
1Microsatellite Instability
06/2009
1Synovial Sarcoma (Synovioma)
04/2008
1Genomic Instability
08/2007
1Fibrosis (Cirrhosis)
02/2006
1Chromosome Aberrations (Chromosome Abnormalities)
11/2005

Drug/Important Bio-Agent (IBA)

16Proteins (Proteins, Gene)FDA Link
11/2021 - 05/2003
9DNA HelicasesIBA
10/2018 - 08/2007
8Ascorbic Acid (Vitamin C)FDA LinkGeneric
11/2021 - 01/2010
5Cisplatin (Platino)FDA LinkGeneric
06/2013 - 01/2008
4DNA (Deoxyribonucleic Acid)IBA
01/2019 - 01/2002
4Exonucleases (3' 5' Exonuclease)IBA
01/2018 - 05/2003
4A-Form DNA (A-DNA)IBA
01/2018 - 05/2003
3Reactive Oxygen Species (Oxygen Radicals)IBA
10/2021 - 02/2006
3Poly (ADP-Ribose) Polymerase-1IBA
11/2005 - 05/2003
2Plasminogen Activators (Plasminogen Activator)IBA
12/2015 - 01/2015
2Hydroxyproline (4 Hydroxyproline)IBA
12/2015 - 01/2015
2ribosomal protein S4IBA
01/2015 - 06/2013
2Blood Glucose (Blood Sugar)IBA
06/2010 - 02/2006
2Triglycerides (Triacylglycerol)IBA
06/2010 - 02/2006
2EnzymesIBA
04/2008 - 01/2005
1Peptide Hydrolases (Proteases)FDA Link
11/2021
1Mutant Proteins (Protein, Mutant)IBA
01/2018
1Drinking WaterIBA
01/2018
1ParaffinIBA
07/2015
1Fluorouracil (Carac)FDA LinkGeneric
07/2015
1Formaldehyde (Formol)FDA Link
07/2015
1CytokinesIBA
01/2015
1RecQ HelicasesIBA
09/2014
1PlatinumIBA
06/2013
1Indicators and Reagents (Reagents)IBA
06/2013
1MicroRNAs (MicroRNA)IBA
09/2012
1Oxygen (Dioxygen)IBA
08/2012
1ElementsIBA
08/2012
1Complementary DNA (cDNA)IBA
11/2011
1Oxaliplatin (Eloxatin)FDA LinkGeneric
11/2011
1ResveratrolIBA
03/2011
1LipidsIBA
03/2011
1Werner Syndrome HelicaseIBA
03/2011
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
02/2010
1Phenobarbital (Luminal)FDA Link
02/2010
1Mitochondrial DNA (mtDNA)IBA
06/2009
1EndonucleasesIBA
04/2008
1ChromatinIBA
08/2007
1CholesterolIBA
02/2006
1Insulin (Novolin)FDA Link
02/2006
1Telomerase (Telomerase Reverse Transcriptase)IBA
11/2005
1zeta-GlobinsIBA
09/2002

Therapy/Procedure

2Therapeutics
07/2015 - 06/2013
1Cystectomy
01/2015
1Drug Therapy (Chemotherapy)
06/2013